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Enzyme Information



Serrazimes® may be used for protein digestion or as a systemic protease to support immune, cardiovascular or musculoskeletal health.

This exclusive food grade fungal enzyme system, used in National Enzyme Company products, is obtained by the controlled fermentation of Aspergillus oryzae and Aspergillus melleus. This unique preparation is characterized by its ability to hydrolyze a casein substrate, in a manner consistent with the standardized activity of serrapeptidase.


There is not a published FCC method for determining the activity of serrapeptidase. National Enzyme Company uses an industry- accepted method to standardize Serrazimes® based on serrapeptidase activity. Within the industry serrapeptidase activity is determined by casein hydrolysis. One serrapeptidase unit “U” is defined as the amount of enzyme that will liberate from a standard casein substrate the equivalent of 1.0 μg of tyrosine per minute at pH 9.0 and 37° C. This assay is based on a 20-minute hydrolysis of a standard casein substrate. At the end point of this hydrolysis, any remaining (unaffected) proteins are precipitated from solution using trichloroacetic acid and removed by quantitative filtration. The filtrate is then spectrophotometrically compared to a tyrosine standard curve.


Serrazimes® is a unique enzyme composition that is specially formulated to provide an enzymatic alternative to serrapeptidase.

Shelf Life:

To maintain optimum enzyme activity, this product should be stored in a cool, dry place in a tightly sealed container. When properly stored, this product can be expected to have a shelf life of 24 months.

Typical Side Activities:

Various proteolytic activities


  • Form: Dry powder
  • Color: Light tan
  • Odor: Free of offensive odor
  • Taste: Free of offensive taste
  • Effective pH Range: pH 4.0 to 9.0
  • Optimum pH: pH 6.0 to 9.0
  • Effective Temperature Range:30°C to 55°C
  • Optimum Temperature: 37°C to 47°C

Nothing disclosed above is to be construed as a recommendation to use our product in violation of any patents. The information presented above is believed to be accurate. However, said information and products are offered without warranty or guarantee except as to the composition and purity stated herein since the ultimate conditions of use and variability of the materials treated are beyond our control.

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