Search Enzymes

Enzyme Information



Nattozimes® helps maintain healthy protein metabolism within the digestive tract and systemically.

This food grade fungal enzyme system, used in National Enzyme Company products, is obtained by the controlled fermentation of Aspergillus oryzae and Aspergillus melleus. This unique preparation is characterized by its ability to hydrolyze the peptide linkages of a standard fibrin substrate, in a manner consistent with the activity of nattokinase.


National Enzyme Company standardizes Nattozimes® based on its nattokinase activity. There is not a published FCC method for determining the activity of nattokinase. Within the industry, nattokinase activity can be measured in Fibrinolytic Units (FU). One FU is defined as the amount of enzyme which acts on a standard solution of bovine plasma fibrin at 37°C and pH 8.5 to increase the absorbance of the filtrate (275nm) by 0.01 per minute.


Nattozimes® is a unique enzyme composition that is specially formulated to provide an enzymatic alternative alternative to nattokinase.

Shelf Life:

To maintain optimum enzyme activity, this product should be stored in a cool, dry place in a tightly sealed container. When properly stored, this product can be expected to have a shelf life of 24 months.

Typical Side Activities:

Various proteolytic activities


  • Form: Dry powder
  • Color: Light tan
  • Odor: Free of offensive odor
  • Taste: Free of offensive taste
  • Effective pH Range: pH 2.75 to 9.0
  • Optimum pH: pH 3.75 to 7.75
  • Effective Temperature Range:Up to 60°C
  • Optimum Temperature: 50°C

Nothing disclosed above is to be construed as a recommendation to use our product in violation of any patents. The information presented above is believed to be accurate. However, said information and products are offered without warranty or guarantee except as to the composition and purity stated herein since the ultimate conditions of use and variability of the materials treated are beyond our control.

Technical Data Sheet Download

PDF Download Download PDF